In New York, the simple and naive just-graduated in journalism Andrea Sachs(Anne Hathaway) is hired to work as the second assistant of the powerful and sophisticated Miranda Priestly(Meryl Streep), the ruthless and merciless executive of the Runway fashion magazine. Andrea dreams to become a journalist and faces the opportunity as a temporary professional challenge. The first assistant Emily(Emily Blunt) advises Andrea about the behavior and preferences of their cruel boss, and the stylist Nigel(Stanley Tucci) helps Andrea to dress more adequately for the environment. Andrea changes her attitude and behavior, affecting her private life and the relationship with her boyfriend Nate(Adrian Grenier), her family and friends. In the end, Andrea learns that life is made of choices.