While in his engagement party with doctor Julia(Michelle Monaghan), the IMF agent, Ethan Hunt(Tom Cruise), is invited to a rescue mission of his former prot?g?e. Agent Lindsey Farris(Keri Russell) was trained by him but has been kidnapped by the evil dealer, Owen Davian(Philip Seymour Hoffman). Ethan accepts the assignment and rescues Lindsey with his team, but she is killed by a bomb that has been implanted in her head. Ethan finds that Owen will be in the Vatican and he joins his group to abduct him. They succeeded in their mission, but back in USA they are betrayed, Owen is released by his team and he abducts Julia, bringing her to Shanghai. Owen contacts Ethan and forces him to steal a powerful weapon in order to save the life of Julia.