Cameron Poe(Nicolas Cage), who is a highly decorated United States Army Ranger came to his home of Alabama to his wife, Tricia(Monica Potter). only to run into a few drunken regulars at where Tricia works. Cameron unknowingly kills one of the drunks and was sent to a federal penitentiary for involuntary manslaughter for seven years. Then, Cameron became eligible for parole and can now go home to his wife and daughter, Casey. Unfortunately, Cameron has to share a prison airplane with some of the most dangerous criminals in the country, who somehow took control of the plane and are now planning to escape the country with the plane. Cameron has to find a way to stop them while playing along. Meanwhile, United States Marshal Vincent Larkin(John Cusack) is trying to help Cameron get free and stop the criminals including, Cyrus "The Virus" Grissom.