In Detroit, Clarence Worley goes to the movie theater alone on the day of his birthday to watch three kung-fu movies. The gorgeous Alabama Whitman accidentally drops her popcorns on Clarence and they watch the movie together. Then they eat pieces of pie and they have one night stand. On the dawn, Alabama confesses that she is a call-girl hired to spend the night with him, but she has fallen in love with him. In the morning they get married and Clarence goes to the club where she worked to bring her clothes. However her pimp Drexl Spivey and his partner beat up Clarence and he reacts killing them both. Clarence asks Alabama's suitcase with her clothes and the other girls mistakenly give another one with cocaine. When Clarence discovers the mistake, he decides to travel with Alabama to the house of his friend, the aspirant actor Dick Ritchie, to sell the drug and travel to Mexico. He visits his father Clifford Worley and gives his address to him. But the Sicilian Mafia is the owner of the drug and a group of killers are hunting down Clarnece and Alabama.