Eighteen years after completing their "mission from God", Elwood J. Blues is released from prison only to learn of the deaths of his brother and partner in crime, 'Joliet' Jake Blues, and his father figure and mentor, Curtis, as well as the destruction of the orphanage he was raised in. With no family, no roots, and no life, a discouraged Elwood goes to meet with Sister (now Mother) Mary Stigmata. At this meeting, in addition to getting stuck mentoring a wise-ass orphan named Buster, Elwood learns of the existence of Curtis' illegitimate son, Cable. Now determined to seek out the only family he has left and to reassemble The Band, Elwood, with the help of his new associate and lead singer, 'Mighty' Mack McTeer, embarks on a death-defying journey that will pit them against the Russian Mafia, a Neo-Confederate Militia, the State Police and the FBI, and end with The Band competing in a Battle of the Bands competition against The Louisiana Gator boys led by B.B. King!