The title refers to the film's hero, Wing Foot (Richard Dix), who is a Navaho educated in an otherwise all-white school. In the course of the story, he experiences prejudice from both the whites (because of his race) and the Navahos (who disown him because of his upbringing). Thus, Wing Foot is looked upon as neither Indian nor white, but simply a "redskin."
The government agent who beats Wing Foot in the beginning of the picture eventually emerges as a decent man - some one who made a mistake and later regretted it. At the end he redeems himself by aiding Wing Foot in his attempt to register his oil claim. Redskin presents not only the conflict between whites and Indians, but also between the Indian races (Navajos and Pueblos are shown to dislike each other).