U.S. Navy SEAL Lieutenant Shane Wolfe (Vin Diesel) is assigned to rescue Howard Plummer (Tate Donovan), a man working on a top-secret government project, from a group of Serbian rebels. Wolfe and his team manage to get Plummer off an enemy boat; moments later, Wolfe and Plummer are shot while boarding the escape helicopter. Plummer is killed in the attack and Wolfe spends two months in the hospital. Wolfe's commanding officer, Captain Bill Fawcett (Chris Potter), is assigned to escort Plummer's widow, Julie (Faith Ford), to Zurich, where a safety deposit box belonging to the Plummers has been discovered. Wolfe is assigned to stay at the Plummer residence, in Bethesda, Maryland to search for the secret project called GHOST, hidden somewhere in the house, and to look after the family's five children: Zoe (Brittany Snow), Seth (Max Thieriot), Lulu (Morgan York), Peter (Logan and Keegan Hoover), and Baby Tyler (Bo and Luke Vink). But the kids prove to be difficult to handle, even with the help of nanny Helga (Carol Kane).