It's 1818 in Hampstead Village on the outskirts of London. Poet Charles Brown lives in one half of a house, the Dilkes family who live in the other half. Through their association with the Dilkes, the fatherless Brawne family know Mr. Brown. The Brawne's eldest daughter, Fanny Brawne, and Mr. Brown don't like each other. She thinks he's arrogant and rude, and he feels that she is pretentious, knowing only how to sew (admittedly well as she makes all her own fashionable clothes), flirt and give opinions on subjects about which she knows nothing. Insecure struggling poet John Keats comes to live with his friend, Mr. Brown. Miss Brawne and Mr. Keats have a mutual attraction to each other, a relationship which however is slow to develop in part since Mr. Brown does whatever he can to keep the two apart. But other obstacles face the couple, including their eventual overwhelming passion for each other clouding their view of what the other does, Mr. Keats' struggling career which offers him little in the way of monetary security (which will lead to Mrs. Brawne not giving consent for them to marry), and health issues which had earlier taken the life of Mr. Keats' brother, Tom.