When a planet is near to be destroyed, two alien offspring are saved by their parents that launch them to the space in pods. Their fate on Earth is opposite: one that is a beautiful baby with superpowers crashes in the lawn of a mansion, while the other that is ugly and blue with a big head crashes in a prison yard with his companion Minion. They are raised in different environments of the Metro City but studying in the same school for gifted children. While one becomes popular but selfish, the other is absolutely outcast. They become enemies and when they grow-up, the population knows them as the superhero Metro Man(Brad Pitt) and the villain Megamind(Will Ferrell). In their fights, Megamind always loses and ends in prison; however, Megamind develops a ray that kills Metro Man, reducing him to a skeleton. After a short period, Megamind feels bored without the battles against Metro Man. Meanwhile he dates the field reporter Roxanne Ritchie(Tina Fey), who works with the cameraman Hal Stewart(Jonah Hill), using the identity of Bernard and sooner they fall in love with each other. When Megamind decides to create another superhero to become his opponent, he accidentally transforms Al Stewart in Titan who becomes greed and evil and destroys Metro City. Now Megamind is the only hope to save the word from the mean Titan
