In 1967, the orphan Norbit(Eddie Murphy) was abandoned by his parents when he was a baby. He was raised by the owner of the orphanage Mr. Wong(Eddie Murphy), and becomes a great friend of the also orphan Kate(Thandie Newton). When Kate is adopted, Norbit feels lonely but is protected by the fat and big Rasputia(Eddie Murphy). They grow up, Rasputia becomes a monstrous woman and they get married. When Kate returns to her hometown decided to buy Mr. Wong's orphanage, Norbit recalls his good moments and falls in love for her. But Rasputia, her gangster brothers and Kate's fianc? Deion Hughes(Cuba Gooding Jr.) have other intentions with the orphanage.