Through contact with a mysterious substance, called Ooze, 4 little turtles in the canalization of New York mutate to giant turtles. They can speak, walk upright and love pizza. The wise rat Splinter(Kevin Clash) becomes their mentor and educates them to Ninja fighters. Their arch-enemy is the bad, bad guy Shredder(James Saito), who struggles to gain power over the world. Of course the ninja turtles will do everything to stop him.