Fashion designer Anita(Joely Richardson) and computer-game writer Roger(Jeff Daniels) meet, fall in love and marry along with their dalmatians Perdita and Pongo. But the proud dogs' puppies are kidnapped by Anita's boss Cruella De Vil(Glenn Close), who is stealing young dalmatians to make the coat she has set her heart on. Enlisting the help of the British animal kingdom, Pongo and Perdita set out to find and rescue all ninety-nine pups from their fearsome captors, Jasper(Hugh Laurie) and Horace(Mark Williams).