This is the story of a boy named Jimmy Livingston who was born without an immune system. Because of this, he is forced to live in a bubble dome in his bedroom, which has led students at a local high school to nickname him Bubble Boy. But when Jimmy discovers that a new girl, Chloe, has moved in next door, he is immediately taken with her beauty. They immediately become fast friends, much to Mrs. Livingston's jealousy. One day, Chloe announces that she is leaving for Niagara Falls to marry Mark, a man who always ridiculed Jimmy. And so Jimmy builds a mobile bubble suit and sneaks off into the night, determined to stop the wedding before it is too late.