In ancient Egypt, high priest Imhotep(Arnold Vosloo) started a forbidden relationship with Anck Su Namun(Patricia Velasquez), Pharaoh Seti(Aharon Ipal?)'s Mistress. When Seti finds out about what's going on, Imhotep and his loved one stab him, but can't escape the trustworthy guards: Anck Su Namun chooses to commit suicide while Imhotep is bestowed with the Hom-Dai, the most feared curse of all: He is mummified alive in Hamunaptra, the city of the Dead. More than thirty-six centuries later, in 1923, to be exact, adventurer Rick(Brendan Fraser) leads Egyptologist Evelyn(Rachel Weisz) and her brother Jonathan(John Hannah) to mysterious Hamunaptra. While Jonathan is keen on finding the legendary Egyptian treasures, Evelyn wants to search for the Book of the Living. Unfortunately, they and a rivaling group of careless American adventurers free Imhotep's mummy from his eternal prison. Now, with the ancient and quite agile high priest on the loose, the adventurers and scientists face not only a dangerous enemy, but also a massive threat to today's world: Imhotep wants to bring Anck Su Namun back to life by using Evelyn's body.