Lions for Lambs begins after two determined students at a West Coast University, Arian and Ernest, follow the inspiration of their idealistic professor, Dr. Malley, and attempt to do something important with their lives. But when the two make the bold decision to join the battle in Afghanistan, Malley is both moved and distraught. Now, as Arian and Ernest fight for survival in the field, they become the string that binds together two disparate stories on opposite sides of America. In California, an anguished Dr. Malley attempts to reach a privileged but disaffected student who is the very opposite of Arian and Ernest. Meanwhile, in Washington D.C. the charismatic Presidential hopeful, Senator Jasper Irving, is about to give a bombshell story to a probing TV journalist that may affect Arian and Ernest's fates.